Humanin 10mg

R910,00

Humanin 10mg

Humanin 10mg

Neuroprotection, Oxidative Stress, Toxicity, Inflammation, Metabolic Health, Insulin Sensitivity, Cardiovascular Health.

R910,00

Out of stock

What It Is?

Humanin is a lab-made synthetic version of a naturally occurring 24-amino-acid mitochondrial-derived peptide (MDP) encoded in the mitochondrial 16S rRNA gene. Discovered in 2001 while screening for factors that protect neurons from Alzheimer’s-related toxicity, it acts as a stress-response signal from mitochondria to the rest of the cell. Humanin (and its potent analogs like HNG/S14G) is studied for cytoprotective, neuroprotective, and metabolic effects.

Think of Humanin as your mitochondria’s ’emergency SOS signal’ that protects cells under stress and promotes healthy aging.
How it works (super simple):
– Binds receptors (e.g., FPRL1, CNTFR/WSX-1/gp130) and directly inhibits pro-apoptotic proteins (Bax/Bid) at the mitochondrial membrane.
– Activates survival pathways (STAT3, ERK, AKT), reduces oxidative stress, and improves mitochondrial function/insulin sensitivity.

Main benefits (strongest from preclinical models and human correlations):
– Neuroprotection: shields neurons from amyloid-beta toxicity, oxidative stress, and inflammation; potential in Alzheimer’s, Parkinson’s, and stroke models.
– Metabolic health & insulin sensitivity: improves glucose metabolism, reduces body weight gain in obesity/PCOS models, and enhances exercise adaptations.
– Longevity & health span: correlates with longer lifespan in mice; analogs extend median lifespan and reduce inflammation in midlife treatment studies.
– Bonus signals: cardio protection, anti-inflammatory effects, and support for reproductive/ovarian health in aging models.
In short: It helps cells survive stress and age more gracefully by optimizing mitochondrial signaling – one of the most promising MDPs for anti-aging research.

Humanin shows an excellent short-term safety profile in preclinical and limited human correlation studies — endogenous and generally well-tolerated.
In available data: No major toxicities; effects are context-dependent (beneficial in most stress models).
Mild/rare effects:
– Possible transient metabolic shifts (e.g., mild glucose changes – monitor in diabetics).
– Injection-site irritation (rare).
Bigger caveats:
– Unknown ultra-long-term human effects -no large therapeutic trials; some contexts may promote certain inflammatory or tumor-related pathways (theoretical).
– Sex-dependent responses noted in some models.
Bottom line: Appears very safe at research doses – far cleaner than many synthetic peptides – but human data is still emerging.

Reconstitution, dosage and cycling protocols for research purposes.

Method of Administration: Subcutaneous into fatty tissue.

Reconstitution: 2ml Bac water into single vial. See Reconstitution Guide

Dose: 2mg daily, therefore 20 units or 0.2ml. Use peptide calculator (link) for alternative dosage.

Course: 20 days.

Cycling: Repeat every 3 months for maintenance or as needed (e.g., during respiratory seasons or after illness).

  • Mitochondrial messenger – the first discovered MDP (mitochondrial-derived peptide); encoded in mtDNA and signals to the nucleus during stress.
  • Alzheimer’s discovery – found while hunting for factors that protect surviving brain cells in Alzheimer’s patients.
  • Lifespan link – higher natural levels correlate with longer life in mice; midlife treatment with analog HNG extends health span.
  • 24-amino-acid mini-protein – small but mighty; a potent analog (HNG/S14G) is 1,000× stronger than natural Humanin.
  • Insulin sensitizer – improves glucose metabolism and exercise adaptations without the downsides of full growth hormone.
  • Sex-specific nuances – effects can differ between males and females in some models.
  • Research rising star – still actively studied in 2026 for neurodegeneration, metabolism, and healthy aging.

Human data is mostly correlative (levels in aging/AD); strongest evidence is preclinical (mice, cells) with promising longevity/metabolic signals.
1. Coradduzza et al. (2023 PMC): Comprehensive review – Humanin improves glucose/insulin sensitivity in animal models; links to aging, metabolism, and cytoprotection.
2. The Peptide Catalog (Feb 2026): Dosing guide — 100–300 mcg research range; mechanisms (Bax/Bid inhibition, STAT3 activation); longevity protocols.
3. Swolverine (Jul 2025): Beginner guide – neuroprotective, metabolic, and anti-aging benefits; safe endogenous peptide.
4. ScienceDirect overview: Protective effects in neurons, leukocytes, gonadal cells; stress resistance and potential in neurodegeneration.
5. Peptide Calculator App (Dec 2025): Dosage/mechanism – insulin sensitivity, neuroprotection; 100–1000 mcg ranges in research.
6. Yen et al. (2013 PMC): Emerging role in stress resistance; cytoprotective against oxidative stress, hypoxia, etc.
7. Aging-US (Jun 2020): Humanin regulates lifespan/healthspan in mice; midlife HNG treatment improves metabolic parameters and reduces inflammation.
8. Paragon Sports Medicine (2026): Energy & healthy aging — mitochondrial optimization, cellular protection; research-only status.
9. Alzheimer’s Drug Discovery Foundation (updated references): Evidence summary – neuroprotective in AD models; insulin sensitivity and healthspan benefits; no human therapeutic trials yet.
10. ResearchGate / lifespan study (Dec 2025 update): Midlife HNG extends healthspan and lifespan in mice; first demonstration of MDP regulating longevity.

Takeaway: Strong preclinical longevity/neuroprotection data + human correlations; we need large clinical trials for therapeutic validation.

Important disclaimer upfront: Humanin is NOT approved by the FDA (or any major Western agency) as of 2026. It remains strictly investigational/research chemical in the US (compounded versions face restrictions under 2026 peptide rules). It is approved and widely used in Russia as a prescription medication for immune restoration. Long-term safety data in healthy Western populations is limited. It is banned by WADA. Always talk to a doctor – this is not medical advice.
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